Retrograde memory enhancement and stress
Jun. 28th, 2006 06:52 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
anhinga_draftsThere is too many notes related to 10th ICCNS conference to be made. So I'll probably keep them here and will make digests in the main journal once in a while.
Various retrograde amnesia effects are well known. James McGaugh of the University of California at Irvine demostrated the effects of retrograde memory enhancement if norepinephrine is increased after a learning experience (via stress or some other mechanism, like direct injection of norepinephrine or cortisol, or stimulation of the BLA (basolateral complex of the amygdala).
The retrograde enhancement effects are strongest if this is done with 30 minute after the learning experience, still noticeable if the delay is up to 2 hours.
BLA projects to a number of areas, including hippocampus, striatum, and cortical regions. McGaugh claims sex differences, that in females it's left amydgala, and in males it's right amygdala, which plays this role.
Somebody (I am not sure whether it was in this talk, or in a related talk), claimed that a more localized norepinephrine boost results in a more specialized memory enhancement, e.g. a boost to hippocampus only would do this selectively, namely for positional memory only.
An interview by the author for general public in 2003.
Or, and I finally understood where the term (nor)epinephrine came from (as a more standard English name for (nor)adrenaline) :-) Took me a "few years" :-)
Various retrograde amnesia effects are well known. James McGaugh of the University of California at Irvine demostrated the effects of retrograde memory enhancement if norepinephrine is increased after a learning experience (via stress or some other mechanism, like direct injection of norepinephrine or cortisol, or stimulation of the BLA (basolateral complex of the amygdala).
The retrograde enhancement effects are strongest if this is done with 30 minute after the learning experience, still noticeable if the delay is up to 2 hours.
BLA projects to a number of areas, including hippocampus, striatum, and cortical regions. McGaugh claims sex differences, that in females it's left amydgala, and in males it's right amygdala, which plays this role.
Somebody (I am not sure whether it was in this talk, or in a related talk), claimed that a more localized norepinephrine boost results in a more specialized memory enhancement, e.g. a boost to hippocampus only would do this selectively, namely for positional memory only.
An interview by the author for general public in 2003.
Or, and I finally understood where the term (nor)epinephrine came from (as a more standard English name for (nor)adrenaline) :-) Took me a "few years" :-)
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no subject
Date: 2006-06-28 11:55 pm (UTC)да, это когда стирается то, что раньше помнил..
от мозговых травм довольно часто бывает -- чем ближе к моменту травмы, тем более полно стирается.. более старые воспоминания труднее стереть..
no subject
Date: 2006-06-28 11:59 pm (UTC)no subject
Date: 2006-06-29 12:09 am (UTC)Считается, что процесс консолидации и переписывания никогда не прекращается, и поэтому она "забирается все глубже".. А толком ничего непонятно :-) Нет толковой теории долговременной памяти..
Но забавно, что можно избирательно стирать, -- если вспомнить в плохом состоянии (скажем, когда синтез протеинов подавлен), тогда то, что вспомнил, сотрется..
no subject
Date: 2006-06-29 12:16 am (UTC)no subject
Date: 2006-06-29 12:27 am (UTC)потом, кажется конкретные кусочки памяти можно "заиграть", если с ними неаккуратно обращаться, -- образуются какие-то "шумовые ассоциации", которые потом делают ёё менее пригодной..
наивно считается, что "use it, or lose it", но, на самом деле, с памятью всё совсем не так устроено..
но если совсем ингибировать синтез протеинов, то стирается без остатка (но только та, которая используется в период ингибирования, та, которая оставалась пассивной, не портится).. видимо, нужна какая-то реконсолидация после использования, и без нёё хана конкретному воспоминанию, -- но тоже ничего больше неизвестно про то, как именно это устроено..
no subject
Date: 2006-06-29 12:18 am (UTC)no subject
Date: 2006-06-29 12:33 am (UTC)это всё очень плохо изучено..
no subject
Date: 2006-06-29 12:41 am (UTC)